A sustained release lubrication method of agarose-sodium hyaluronate hydrogels for artificial joint.

Abstract

The artificial joint prosthesis's surface is subjected to wear due to the destruction of the joint lubrication environment after surgery. In this study, an agarose-sodium hyaluronate hydrogel was used as lubricant additive in order to supply and preserve the lubricating fluid of artificial joint prostheses. A ball on disc experiment was conducted using this hydrogel to evaluate the lubrication efficiency and release rate under various frequencies. The results showed that this hydrogel could release lubricant under pressure and then absorb the released fluid after decompression. Furthermore, the agarose-sodium hyaluronate hydrogel acted as an effective transport mechanism to release sodium hyaluronate lubricant into the metal-on-polymer friction interface. Compared with pure water lubrication, the friction coefficient and wear volume were reduced by up to 62.9%, and 86.9% respectively. Moreover, the proposed lubrication method provided a long-term lubrication on artificial hip joints.