Abstract
Malignant hyperthermia (MH) is a rare, life-threatening, hereditary skeletal muscle disorder characterized by a hypermetabolic response following exposure to potent, volatile anesthetics or depolarizing muscle relaxants, such as halothane, desflurane, sevoflurane, and succinylcholine.1-4 MH is associated with genetic mutations of the ryanodine receptor gene (RYR1), which codes the skeletal muscle calcium-release channel. Increased Ca2+ concentrations in extracellular fluid play an essential role in the pathogenesis of MH.
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