A survival comparison of gastric mucin-producing adenocarcinoma to conventional adenocarcinoma: a SEER database analysis

Qiang Wang,Junbin Zhong,Zhuanpeng Chen,Qing Huang,Jie Cao,Jianchang Wei,Fang Wei

doi:10.1186/s12885-021-08835-z

Abstract

BackgroundCompared to conventional adenocarcinoma (CA), mucin-producing adenocarcinoma (MPA) is an uncommon histological subtype and is usually separated from other histological types and has been evaluated separately. The objective was to compare the clinicopathological characteristics and survivals of MPA with CA.MethodsWe retrospectively analyzed 1515 MPA patients in SEER database. Log-rank tests and KM survival curves were applied to determine the differences in overall survival (OS) and cancer specific survival (CSS) time.ResultsNo significant differences were noted in OS and CSS time. The MPA patients who were treated with surgery and chemotherapy exhibited longer OS and CSS time periods than those without treatment. MPA patients treated with radiotherapy exhibited similar OS and CSS time with those without radiotherapy. MPA was not a prognostic factor of survival.ConclusionsMPA was a rare histological type of gastric cancer. Patients with MPA exhibited similar prognosis with those with CA. Surgery and chemotherapy were effective treatments for patients with MPA.

Highlights

Compared to conventional adenocarcinoma (CA), mucin-producing adenocarcinoma (MPA) is an uncommon histological subtype and is usually separated from other histological types and has been evaluated separately
A total of 5689 eligible patients were selected from the SEER database during the period 2004–2015, of which 1515 patients (26.6%) presented with MPA and 4174 patients (73.4%) with CA
Age, gender, race, tumor differentiation, clinical stage, T stage, N stage, surgery and chemotherapy were significantly different between MPA and CA, i.e., patients in the MPA group exhibited younger, more females, more black people, more poor/undifferentiated tumors, later clinical stage, more T3, T4, N2 stages, more surgery and chemotherapy than those of the CA group

Summary

Introduction

Compared to conventional adenocarcinoma (CA), mucin-producing adenocarcinoma (MPA) is an uncommon histological subtype and is usually separated from other histological types and has been evaluated separately. Differentiated cancers include well differentiated, moderately differentiated and papillary adenocarcinomas, whereas, undifferentiated tumors include signet ring cell carcinoma, Mucin-producing adenocarcinoma (MPA), such as mucinous adenocarcinoma and signet ring cell carcinoma, have the characteristics of producing mucin by the presence of intracellular or extracellular mucin pool [4]. Mucinous adenocarcinoma is characterized with more than 50% of extracellular mucin, and signet-ring cell carcinoma is characterized with more than 50% cells that contain intracellular mucin. The latter cause a certain movement of the nucleus to one side in order to create the characteristic morphology [5]. Compared to conventional adenocarcinoma (CA), MPA is an uncommon histological subtype and is considerably different in morphology, cell characteristics and protein expression

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Discussion

Conclusion