Abstract

Pneumococcal surface protein A (PspA) Protective aganist multiple pneumococcal serotypes in mice models of invasive disease pneumonia, and colonization. Vaccination of healthy volunteers with PspA generated antibodies aganist multiple strains that protected mice aganist invasive disease. Human studies in progess. Pneumolysins.Pneumolysoids Protection aganist Pneuminia and increased survival after intraperitoneal challenge. human studies in progress Neuraminidases (Nan) Protection aganist colonization and otitis media Pneumococcal surface protein C (PspC) Protection aganist colonization. Protection aganist sepsis Pneumococcal protective protein A (PppA) Protection aganist lung infection. Protective aganist nasopharyngeal colonization. Pneumococcal Histidine Trial Protein D Protective aganist animal models of invasive disease and pneumonia phase II trial reports awaited. IC4 antigens Protection aganist sepsis, pneumonia, nasopharyngeal carriage.

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