Abstract
This chapter presents a survey of covalent, ionic, and radical intermediates in enzyme-catalyzed reactions. In addition to covalently attached intermediates, many enzymes form tight complexes with covalent reaction intermediates, while others mediate free radical reactions. Covalent catalysis is necessary in most of the enzyme processes. These covalent intermediates facilitate catalysis by providing (1) a mechanism for preserving the group transfer potential in multistep reaction schemes, (2) a means for converting an atom or group of atoms into a better leaving group in nucleophilic reactions, (3) a physical way for transferring a reactant between topologically distant active sites on multifunctional enzymes, and (4) a capacity for creating timers, latches, and clamps. The chapter presents nearly 300 such reactions in a tabular form and, where possible, includes Enzyme Commission classification numbers.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
