Abstract

The present study was performed to establish a novel ocular surgery simulator for training in peeling of the inner limited membrane (ILM). This simulator included a next-generation artificial ILM with mechanical properties similar to the natural ILM that could be peeled underwater in the same manner as in actual surgery. An artificial eye consisting of a fundus and eyeball parts was fabricated. The artificial eye was installed in the eye surgery simulator. The fundus part was mounted in the eyeball, which consisted of an artificial sclera, retina, and ILM. To measure the thickness of the fabricated ILM on the artificial retina, we calculated the distance of the step height as the thickness of the artificial ILM. Two experienced ophthalmologists then assessed the fabricated ILM by sensory evaluation. The minimum thickness of the artificial ILM was 1.9 ± 0.3 μm (n = 3). We were able to perform the peeling task with the ILM in water. Based on the sensory evaluation, an ILM with a minimum thickness and 1000 degrees of polymerization was suitable for training. We installed the eye model on an ocular surgery simulator, which allowed for the performance of a sequence of operations similar to ILM peeling. In conclusion, we developed a novel ocular surgery simulator for ILM peeling. The artificial ILM was peeled underwater in the same manner as in an actual operation.

Highlights

  • A macular hole is a foveal defect located at the center of the macula that can induce retinal tears and rhegmatogenous retinal detachments [1]

  • To fabricate the artificial inner limiting membrane (ILM), a hydrogel obtained by chemically crosslinking poly(vinyl alcohol) (PVA) was used as the main material and processed into a thin film [21,22,23]

  • To evaluate whether this system is suitable for training of novice surgeons, Table 1 shows the sensory evaluation with different film thicknesses and molecular weights of the main material

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Summary

Introduction

A macular hole is a foveal defect located at the center of the macula that can induce retinal tears and rhegmatogenous retinal detachments [1]. A harvested inner limiting lamina often includes an epiretinal membrane (ERM) on the inner limiting membrane (ILM) with adherent cells [2,3,4,5]. Treatment of the macular hole removes the ERM, and an ILM peeling procedure has been suggested to decrease the risk of retinal detachment [2]. In addition to removal of the ERM, peeling of the ILM improves the therapeutic effect for the macular hole [6,7,8].

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