Abstract
Photodynamic therapy (PDT) as a safe, non-invasive modality for cancer therapy, in which the low oxygen and high glutathione in the tumor microenvironment reduces therapeutic efficiency. In order to overcome these problems, we prepared a supramolecular photosensitive system of O2-Cu/ZIF-8@ZIF-8@WP6–MB (OCZWM), which was loaded with oxygen to increase the oxygen concentration in the tumor microenvironment, and the Cu2+ in the system reacted with glutathione (GSH) to reduce the GSH concentration to generate Cu+. It is worth noting that the generated Cu+ can produce the Fenton reaction, thus realizing the combination therapy of PDT and chemodynamic therapy (CDT) to achieve the purpose of significantly improving the anti-cancer efficiency.
Highlights
Photodynamic therapy (PDT) as a safe, non-invasive modality for cancer therapy, in which the low oxygen and high glutathione in the tumor microenvironment reduces therapeutic efficiency
In PDT application, chemodynamic therapy (CDT), as a recent and emerging treatment method, produces hydroxyl radicals through the Fenton-like or Fenton reaction with hydrogen peroxide in cancer cells, and triggers the apoptosis of cancer cells, which is often combined with PDT to improve therapeutic effect [9,10]
Zeolitic imidazolate frameworks-8 (ZIF-8)@DOX, we have developed a supramolecular tween water-soluble carboxylated pillar[6]arene (WP6) and ZIF-8@DOX, we have develtargeted drug hybrid material with good dispersion efficiency, and host–guest complexoped a supramolecular targeted drug hybrid material with good dispersion efficiency, ation of as necessary modifiers to improve it0s water dispersion and give it and host–guest complexation of water-soluble carboxylated pillar[6]arene (WP6) and G as necessary modifiers to improve it0s water target properties
Summary
Photodynamic therapy (PDT) as a safe, non-invasive modality for cancer therapy, in which the low oxygen and high glutathione in the tumor microenvironment reduces therapeutic efficiency. In order to improve the problems encountered by PSS in PDT application, chemodynamic therapy (CDT), as a recent and emerging treatment method, produces hydroxyl radicals through the Fenton-like or Fenton reaction with hydrogen peroxide in cancer cells, and triggers the apoptosis of cancer cells, which is often combined with PDT to improve therapeutic effect [9,10]. The development of a new supramolecular PSs-MOFs carriers to maintain or even improve the efficiency of PDT can overcome the photobleaching and dark toxic effects of PSs, and the combination therapy of PDT and CDT can be achieved
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