Abstract
Superabsorbent polymer (SAP)-containing wound dressings present a valuable and unique category of wound management products. An in vitro approach was used to assess the effects of a new SAP dressing in treatment of non-healing wounds. It was shown that the SAP dressing possesses a significant binding capacity for MMP-2 and MMP-9 in vitro (P < 0.001). The inclusion of the bound proteases was so strong that no MMP-2 and only marginal amounts of MMP-9 were released from the dressing samples in a subsequent elution step. In addition, the SAP dressing was able to take up collagenase and reduce its activity in vitro. However, collagenase was not completely inactivated upon binding and enzyme-mediated substrate turnover could be observed at the dressings. In conclusion, in vitro data confirm the positive effect of the SAP wound dressing observed in vivo. The findings suggest that it should be specifically useful for highly exuding wounds with an elevated proteolytic activity that needs to be reduced to support healing.
Highlights
Non-healing wounds, like venous, pressure and diabetic ulcer, have become a rising charge to society as an increasing number of patients suffer from wounds that fail to heal
The findings suggest that it should be useful for highly exuding wounds with an elevated proteolytic activity that needs to be reduced to support healing
It was observed that the protease was so tightly bound by the Superabsorbent polymer (SAP) dressing samples that even disruption of the dressing and aggressive elution techniques did not lead to the release of matrix metalloproteinases (MMPs)-2 in vitro
Summary
Non-healing wounds, like venous, pressure and diabetic ulcer, have become a rising charge to society as an increasing number of patients suffer from wounds that fail to heal. Several studies have shown that exudates from these chronic wounds are characterized by elevated levels of matrix metalloproteinases (MMPs) [1, 2], contain excessive amounts of polymorphonuclear granulocyte-derived elastase (PMN elastase) [3,4,5], and high concentrations of free radicals [6]. These inflammatory mediators shift the balance of matrix synthesis and its degradation towards tissue destruction. The resulting polyacrylate superabsorbers have a high density of ionic
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