Abstract
A glycopeptide sulfate (GLPS), previously described as an effective anti-ulcer agent with antipeptic and antisecretory properties in rats, was tested on histamine-induced gastric and duodenal ulcers in guinea pigs. GLPS, orally administered at doses over 100 mg/kg, protected the animals against both type of lesions. With the highest doses (245–600 mg/kg) employed in the duodenal ulcer test, GLPS reduced gastric acid secretion to normal values and completely abolished peptic activity.
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Schedule a callMore From: European Journal of Pharmacology: Molecular Pharmacology
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