Abstract
Dipsogenic diabetes insipidus (DDI) is a subtype of primary polydipsia (PP), which occurs mostly in healthy people without psychiatric disease. In contrast, PP is characterized by a polyuria polydipsia syndrome (PPS) associated with psychiatric illness. However, the pathogenesis of DDI is not well established and remains unexplored. In order to diagnose DDI, the patient should exhibit excessive thirst as the main symptom, in addition to no history of psychiatric illness, polyuria with low urine osmolality, and intact urine concentrating ability. Treatment options for DDI remain scarce. On this front, there have been two published case reports with successful attempts at treating DDI patients. The noteworthy commonalities in these reports are that the patient was diagnosed with frequent excessive intake of water due to a belief that drinking excess water would have pathologic benefits. It could therefore be hypothesized that the increasing trend of excessive fluid intake in people who are health conscious could also contribute to DDI. Hence, this review provides an overview of the pathophysiology, diagnosis, and treatment, with a special emphasis on habitual polydipsia and DDI.
Highlights
With the increasing acceptance of lifestyle programs and the common belief that drinking several liters of fluid per day is healthy, the prevalence of this phenomenon is increasing, outside of the psychiatric setting [1,2]. This phenomenon which occurs in healthy people without psychiatric disease, seems to be closely related with dipsogenic diabetes insipidus (DDI)
This review is intended to provide a summary of the pathophysiology, diagnosis, and care, with a particular focus on the possibility that Dipsogenic diabetes insipidus (DDI) may be triggered by habitual polydipsia
DDI is a polyuria polydipsia syndrome (PPS) that mostly occurs in healthy people without psychiatric disease, in contrast to primary polydipsia (PP) that occurs in patients with psychiatric disease
Summary
With the increasing acceptance of lifestyle programs and the common belief that drinking several liters of fluid per day is healthy, the prevalence of this phenomenon is increasing, outside of the psychiatric setting [1,2]. This phenomenon which occurs in healthy people without psychiatric disease, seems to be closely related with dipsogenic diabetes insipidus (DDI). DDI is defined as a rare non-psychiatric syndrome of disordered thirst, in which the osmotic threshold for thirst is abnormally low, below the threshold for antidiuretic hormone (ADH) release [3]. This review is intended to provide a summary of the pathophysiology, diagnosis, and care, with a particular focus on the possibility that DDI may be triggered by habitual polydipsia
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
