Abstract
In his most celebrated tale “The Picture of Dorian Gray”, Oscar Wilde stated that “those who go beneath the surface do so at their peril”. This sentence could be a prophetical warning for the practitioner who voluntarily challenges himself with trying to synthesize marine sponge-deriving pyrrole-imidazole alkaloids. This now nearly triple-digit membered community has been growing exponentially in the last 20 years, both in terms of new representatives and topological complexity – from simple, achiral oroidin to the breathtaking 12-ring stylissadines A and B, each possessing 16 stereocenters. While the biosynthesis and the role in the sponge economy of most of these alkaloids still lies in the realm of speculations, significant biological activities for some of them have clearly emerged. This review will account for the progress in achieving the total synthesis of the more biologically enticing members of this class of natural products.
Highlights
Sometime in 2003, our Company decided to set up a new project based upon the chance of fishing out new potent and selective kinase inhibitors from the natural products armoury
The first total synthesis of (-)-dibromophakellstatin 32 was accomplished by the Lindel group [98], who exploited the enantioselective version of their three-component imidazolinone annulation on a tricyclic enamide with TsONHCOOEt [92,93] (Scheme 8)
Ageliferins (9, 88 and 89, Figure 9) are dimeric pyrrole-imidazole alkaloids that have been isolated from the sponge Agelas conifera [136, 143]
Summary
Barbara Forte 1, Beatrice Malgesini 2, Claudia Piutti 1, Francesca Quartieri 2, Alessandra. Dedicated to our colleague and friend Dr Sergio Mantegani, in recognition of his merits in natural products chemistry, and in appreciation of his relentless endeavor to teach, advise and share his chemistry skills in our organization. Received: 30 October 2009; in revised form: 20 November 2009 / Accepted: 26 November 2009 /
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