Abstract
2-methylresorcinol (2-MR) was administered to groups of 40 male and 35 female Sprague-Dawley rats by admixture with diets at levels of 0.1, 0.4, and 1.5% for periods up to 6 months. Methemoglobin levels were determined after 6 weeks. After 90 days 10 animals/sex/group were killed for clinical pathological and histopathologic determinations. The 25 remaining females and 20 males per group were utilized in teratology and dominant lethal studies presented in Part II ( T. A. Re, R. F. Loehr, S. C. Rodriguez, D. E. Rodwell, C. M. Burnett, 1986, Fundam. Appl. Toxicol. 7, 293–298). Ten additional males were killed after 6 months of exposure for additional clinical pathologic determinations and gross pathologic observations. The 20 males/group used in the dominant lethal study (Part II) were also killed after 6 months to serve as a comparison recovery group (gross examination of organs). Feeding 2-MR at a level of 1.5% in the diet was associated with a significant reduction in body weight gains. Females fed at a level of 0.4% also weighed significantly less than the control. No pathological effects were noted after either 90 or 180 days of feeding.
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