Abstract
The effect of pituitary stalk-section on the hypocalcaemic activity in urine, hypothalamus and pituitary gland was investigated in rats. Intact rats and rats with pituitary stalk-section were made hypercalcaemic and their urines were injected to bio-assay rats. A hypocalcaemic factor was present in the urine of intact hypercalcaemic rats and on the contrary, this factor was absent from the urine of hypercalcaemic rats with pituitary stalk-section. Hypothalamic and pituitary gland extracts obtained twenty-four hours after stalk-section, from guinea pigs, were injected to bio-assay rats. Pituitary extract had no hypocalcaemic activity, whereas hypothalamic extracts produced hypocalcaemia. Neither the injection of pituitary or hypothalamic extracts to TPTX rats produced hypocalcaemic effect.
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