A Study to Find Out the Association of Vitamin D Levels with Leiomyoma Uterus

Abstract

Objective: To find out the the association of vitamin D levels with leiomyoma and to study its role as a riskfactor for development of leiomyoma.Materials & Methods: Total 50 patients, belonging to age group 18-50 years, attending gynaecology OPDof CSS Hospital, were included in this study. Those diagnosed with leiomyoma on ultrasound scan, werelabeled as case group. Control group comprised of 50 women whose pelvic ultrasound was normal andthere was no fibroid. Volume of each fibroid was measured by transvaginal sonography. The quantitativedetection of serum vitamin D levels was performed using chemi-luminescence assay. Statistical analysis wasperformed using suitable tests of significance.Results: The mean level of vitamin D in the case group was 12.9+3.09 ng/ml while in the control groupwas 18.1±4.72 ng/ml (p = 0.001). Out of 50 cases, 32 (44%) cases were deficient i.e.vitamin D levels wereless than 10 ng/ml, while in controls, 15 (14%) were deficient with p value <0.001. In our study 24 cases(48%) were vitamin D insufficient i.e. vitamin D levels between 10-20 ng/ml while 16 (32%) controls wereinsufficient .Conclusions: In this study low levels of vitamin D were associated with a higher risk of uterine fibroids.So vitamin D may be a potential protective factor against the development of leiomyoma. Cohort andInterventional studies are however pressingly needed to confirm a causal relationship and to investigate thepotential therapeutic benefits of vitamin D supplementation. Vitamin D could be a potential safe, nonsurgicaltherapy for the treatment of uterine fibroids.