Abstract
Abstract Background: Diabetes mellitus is a multifactorial disorder characterized by persistent elevation of plasma glucose and permanent complications of both small and large vessels. The high mortality rates, a decline in quality of life, and high morbidity rates are mostly caused by these problems. When blood vessels are injured, the normal hemostatic process depends heavily on platelets to maintain their integrity. Objectives: This study aimed at comparing various platelet indices between people with type II diabetes and people who appeared to be in good health status. Materials and Methods: This case-controlled study was carried out at the Azadi Teaching Hospital’s Laboratory in Duhok. Four milliliters of blood were collected from diabetics and non-diabetic controls into ethylenediaminetetraacetic acid anticoagulant tubes. Glycated hemoglobin and complete blood count were evaluated by automated chemistry analyzer Cobas 6000 (Roche) and automated blood count analyzer (Coulter, Sweden), respectively; platelet parameters including platelet count, platelet distribution width, mean platelet volume, platelet-large cell ratio, and platelet crit were obtained. Diabetic patients were divided into two groups: Group 1 with good glycemic control (HbA1c < 7%) and Group 2 with poor glycemic control (HbA1c ≥ 7%). Statistical software SPSS 26.0 was used. Results: The mean age of diabetic patients in this study was 50.97 ± 10.91 years. The mean values of platelet parameters except for platelet counts were significantly higher among diabetic patients when compared to non-diabetic subjects as well as among diabetic patients with poor glycemic controls compared to those with good glycemic control. Conclusion: All platelet indices apart from platelet count were significantly elevated among patients with diabetes mellitus than healthy subjects and also in relation to the degree of glycemic control of the disease with a P value of <0.05.
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