Abstract
Introduction: Dengue is one of the most serious mosquitos borne viral infection mainly affecting tropical and subtropical countries of the world. In absence of specific treatment and vaccine for dengue fever (DF); vector control is the only method by which spread of dengue can be prevented. The present study was conducted to determine the increasing dengue incidence in Bihar region.
 Material and Method: This study was done to report the sero prevalence of Dengue virus infection at Bihar, North India. The laboratory records of clinically suspected Dengue patients from jan 2018 to Nov 2018 were analyzed retrospectively for demographic features, seasonal variations, and results of IgM and IgG anti dengue antibodies tested by Dengue IGM capture enzyme linked immune sorbent assay (MAC ELISA).
 Results: A total of 1035 serum samples were analyzed. Out of which 209 samples (20.19%) were found positive for dengue virus infection. Maximum positive cases were seen in 2019 (53.11%). Seasonal trend showed that infection started appearing in august, peaked in October and slowly tapered by December.
 Conclusion: The most affected age group was 11 to 15 years of age, (57.3%) followed by 6 to10 year’s group (27.3 %)and least effective age group was 0 to 5 year (15.4%), majority of cases were found to be of secondary dengue virus infection (93.8%). Male to female ratio was 2:1.The present outbreak thus emphasizes the need for continuous sero epidemiological surveillance for the timely formulation and implementation of effective dengue control programme.
 Keywords: Dengue, dengue haemorrhagic fever, IgM antibody capture enzyme linked immune sorbent assay (MAC ELISA), India, vector.
Highlights
Dengue is one of the most serious mosquitos borne viral infection mainly affecting tropical and subtropical countries of the world
Material and Method: This study was done to report the sero prevalence of Dengue virus infection at Bihar, North India
All four serotypes can cause the full spectrum of disease from a subclinical infection to a mild self limiting disease, the dengue fever (DF) and a severe disease that may be fatal, the dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS)
Summary
Dengue is one of the most serious mosquitos borne viral infection mainly affecting tropical and subtropical countries of the world. Dengue viruses (DV) belong to family Flaviviridae and there are four serotypes of the virus referred to as DV-1, DV-2, DV-3 and DV-4.1 It is found mainly in areas of the tropic and sub-tropics It is a positive stranded encapsulated RNA virus and is composed of three structural protein genes, which encode the nucleocapsid or core (C) protein, a membrane-associated (M) protein, an enveloped (E) glycoprotein and seven non-structural (NS) proteins.[2] It is transmitted mainly by Aedes aegypti mosquito and by Aedes albopictus.[3,4] All four serotypes can cause the full spectrum of disease from a subclinical infection to a mild self limiting disease, the dengue fever (DF) and a severe disease that may be fatal, the dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS).
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