A Study to Assess the Role of Date Syrup, Pineapple Juice, and Hematinic Syrup as Magnetic Resonance Oral Contrast Agents in Improving the Image Quality of Magnetic Resonance Cholangiopancreatography.

Abstract

Magnetic resonance cholangiopancreatography (MRCP) is an imaging technique that has advanced over the past few years.It still plays a crucial role in the study of numerous pancreaticobiliary diseases.This study aimed to evaluate the effects of hematinic syrup, date syrup, and pineapple juice on MRCP image quality. This study involved a total of 90 participants, distributed evenly among three groups, with each group comprising 30 patients.Negative oral contrast solutions containing paramagnetic substances like Mn+2 andFe+3, such aspineapple juice, date syrup, and hematinic syrup were imaged by 1.5 Tesla (T) magnetic resonance imaging (MRI) with T2-weighted (T2W) and MRCP sequences. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were computed. Ninety patients underwent MRCP 20-30 min after ingestion of 100 mL of datesyrup, 30 ml of hematinic syrup diluted to 200 ml of water, and 200 mL of pineapple juice. MRCP images were taken to visualize various pancreaticobiliary structures (bile duct, stomach, and duodenum). The in vitro evaluation of the solutions showed that date syrup and hematinic syrup were hypointense in T2W sequences.The images obtained showed no significant difference in the CNR between the three solutions. However, the SNR was significantly higher for pineapple juice compared to date syrup and hematinic syrup in T2W and MRCP sequences.Images acquired post-administration of the oral contrast agents significantly improved the gastrointestinal tract signal suppression and increased visibility of the pancreaticobiliary structures (bile duct, stomach, and duodenum). No adverse events were observed among the participants. Pineapple juice was the best contrast agent. However, date syrup and hematinic syrup can also be used to improve the imaging quality.