A Study onP53Family Genes’ Characteristics Based on the 3-base Periodicity

Abstract

The characteristics of P53 cancer suppressor gene was studied by using the method of signal processing and analysis.To be more specifically,under the Voss numerical mapping,two indicators,the difference(d) between the maximum power spectrum and its one-third and the signal-to-noise ratio(R) were combined to discuss the 3-base periodicity of P53 family genes,as well as using the discrete Fourier transform(DFT).Exons of the DNA sequence of human beings' P53 family(P53、P63 and P73) and house mice' P53 family were selected to study the relation between the 3-base periodicity and exon's length,base composition and base distribution.On the premise of 3-base periodicity theory,the authors analysed P53 genes' codon bias.The result illustrated that,the 3-base periodicity of short exons(N100) in P53 family genes was not obvious,while the 3-base periodicity of longer exons(100≤N1000) in P53 family genes was quite obvious.The exons with the character of 3-base periodicity had a higher content in GC、GC3,and the GC content had obvious relations with spectrum pick value.Also,the 3-base periodicity was related to the composition and distribution of bases.It had the highest possibility that the spectral peak of the 3-base periodicity was G or C,and the content of GC3 was quite high.The R value had a significant relation with frequency of optimal codons(FOP).There was a positive correlation between the spectrum pick value and P53 family genes' codon bias.This research result might lay important theoretical foundation and has prominent practical significance to the further study of P53 family genes.