A study on water intake and food consumption in animals treated with Thyroxine followed by Bauhinia Purpurea and Withania Somnifera - Original Research

Abstract

Background: There has been a tremendous range of interest in drugs obtained from medicinal plants that are believed to be safer with significant efficacy in the treatment of thyroid disorders Objective: to observe the water intake and food consumption in animals treated with Thyroxine followed by Bauhinia Purpurea and Withania Somnifera. Materials and Methods: A total of 30 adult female Albino rats of Wistar Strain weighing 150-230 grams were utilized for the present study. The animals were maintained and the protocol was approved by the Institutional Animal Ethical Committee (No.878/ac/05/CPCSEA/23/11) from Raghavendra Institute of Pharmaceutical Education & Research (RIPER), Anantapur, Andhra Pradesh. The animals were divided into 5 groups and each group consisted of 6 animals in our study Results: The mean water intake rate was significantly decreased (25.94+0.42) in the rats treated with thyroxine (0.5 mg/kg b.w) followed by Bauhinia purpurea (150mg) and Withania somnifera (1000mg) when compared control group was 29.44+0.27. The food consumption rate was significantly increased in the rats treated with Thyroxine(0.5 mg/kg b.w) 21.33+1.71 when compared to the control group in our study Conclusion: The animals treated with thyroxine alone showed increased food consumption compared with other experimental and control groups, whereas water intake was significantly higher in control animals than other experimental groups.