A study on thyroid hormone levels of pregnant women from three hospitals in Urumqi, Xinjiang

Abstract

Objective To investigate the changes of thyroid hormone levels during pregnancy in three hospitals and the prevalence of thyroid disease in Urumqi, Xinjiang. Methods A sample of 792 pregnant women were divided into three groups according gestational weeks, first trimester(A1 group), second trimester(A2 group), third trimester(A3 group)and the number of women were 256, 302, and 200 respectively. 200 healthy non-pregnant women were selected as control group(N group). Electrochemiluminescence was used to measure the levels of thyroxine stimulating hormone(TSH), free 3, 5′-triiodothyronine(FT3), free thyroxine(FT4), TT3, TT4 thyroglobulin antibody(TGAb), anti-thyroid peroxidase antibody(TPOAb). Statistical analysis were performed. Results There were statistical significance between the pregnant groups and control group in FT3, FT4, TT3, TT4, TSH, TGAb, and TPOAb levels (P 30(P 30(P<0.05). The positive rates of TGAb and TPOAb were 10.26% and 2.98% in A3 group, which is significantly lower than A1 group(P<0.01, P<0.05)and A2 group(P<0.01, P=0.01), but higher than N group(P=0.03, P<0.01). The prevalences of thyroid disease in A1 group and A2 group were significantly higher than those of the control group(P=0.010, P=0.018). Conclusion During gestation period, there was obvious correlation between the levels of thyroid hormone and age, which may provide evidence to prevent thyroid disease by strengthen necessity of screening and intervention. (Chin J Endocrinol Metab, 2016, 32: 910-915) Key words: Pregnancy; Thyroid hormones; Age; Hypothyroidism