A Study on the Spectrum of Thyroid Abnormalities in Liver Disease and Its Correlation with Liver Function

Abstract

Introduction: liver diseases are associated with endocrine disturbances and secondary dysfunction of endocrine organwhich apparent hormonal imbalance. This study aims to find out the correlation between the levels of FT3, FT4, TSH andseverity of liver disease in Chronic Liver Disease patients.Materials and Method: A total of 100 subjects with Chronic Liver disease satisfying inclusion and exclusion criteriavisiting medicine OPD and admitted in IPD of Muzaffarnagar Medical College during the period of 18 months was takenfor study which was a Cross Sectional Observational Study.Thyroid function tests which includes FreeT3, FreeT4, TSHwas done for all patients and tests such as Anti-TPO antibodies, USG neck, Doppler thyroid, FNAC thyroid was donewherever indicated The liver function tests including total and direct bilirubin, total protein and albumin, AST and ALT,APTT, PT, INR was done for all patients and USG abdomen and Oesophago-gastro-duodenoscopy was done whereverindicated.Results: The mean duration of liver disease in our study population was 5.92 ± 4.61 years (range 1-26 years). The meanFT3 levelwas 2.3059 ± 0.8883 p Mol/L. The mean FT4 level was1.1689 ± 1.0806 ng/dL . The mean TSH level was 3.3198 ±1.0173 m IU/mL The mean total bilirubin was 8.445 ± 4.3438 mg/dL .Conclusion: Thyroid dysfunction forms important part of spectrum of Chronic liver disease. Patients with liver diseaseshould be evaluated for thyroid dysfunction periodically.