A study on the prevalence, distribution and related factors of heart valve calcification using coronary CT angiography.

Abstract

The concept of active atherosclerotic disease has been accepted for heart valve calcification (HVC). We investigated prevalence, distribution and related factors of HVC in patients who had undergone coronary CT angiography (CCTA). Subjects were consecutive 200 patients who underwent CCTA. The prevalence and the distribution of HVC using ECG gated non-contrast CT were investigated. Logistic regression analysis and simple regression analysis for factors associated with presence of the calcification and quantitative calcification in the aortic and mitral valve were conducted. HVC was detected in 48.0%. Aortic valve calcification (AVC) was found in 92 cases, the most, followed by mitral valve calcification (MVC) in 25 cases, pulmonary valve in 3 cases, and tricuspid valve in 1 case. Although the left coronary cusp showed the most in 65.2%, no statistic significant difference for Agatston score was detected among each cusp in AVC. Multiple logistic regression analysis showed that age (OR:1.211, 95%C.I.:1.0716-1.1728, p<0.0001) and coronary artery calcium score (CACS) grade (grade2 OR:7.3393, 95%C.I.:1.7699-30.4349, p=0.0060, grade3 OR:7.2214, 95%C.I.:1.4376-36.2762, p=0.0164) were significant factors associated with presence of AVC. The significant factors associated with quantitative AVC were age (p=0.0043), dyslipidemia (p=0.0117), and statin use (p=0.0221). Only age (OR:1.1589, 95%C.I.:1.0726-1.2520, p=0.0002) was significant factor related to presence of MVC. No significant related factor was found in quantitative MVC. There was an association between presence of AVC and CACS, but not a significant association with presence of MVC. Neither quantitative AVC nor MVC had a significant association with CACS or coronary artery disease.