A STUDY ON THE PREDICTORS OF MORBIDITY AND MORTALITY IN ORGANOPHOSPHORUS POISONING

Abstract

Background: Poisoning from organophosphorus (OP) pesticides can occur as a result of occupational, accidental, or purposive exposure.Cholinergic syndromes,central nervous system (CNS) disorders,and cardiovascular disorders are some of the clinical manifestations.The most common causes of death are cardiovascular and respiratory failure.Aim:To assess various parameters that can predict the outcome of patients suffering from OP poisoning. Materials and Methods: A prospective study was conducted at Government general hospital vijayawada Over a one-year period of time.The clinical history of OP compound exposure and low blood levels of pseudo cholinesterase were used to make the diagnosis of OP poisoning.Results:The current study enrolled 133 patients, 98.5% of whom were suicidal and only 1.5% were exposed accidentally.The majority of cases involved young males,with an F/M ratio of 1:3.2.Younger people and patients who required prolonged ventilator support had a higher mortality rate.The death rate was proportional to the amount of poison consumed. Lag time,organ failure (Acute Renal Failure),and plasma pseudocholinesterase levels are all factors to consider. Acute complications were frequently observed and treated. There was no clear link found between liver dysfunction, electrolyte imbalance, and clinical outcome. Conclusion: According to this case study, mortality is directly proportional to the lag time, amount of OP substances consumed, and clinical severity.Acute renal failure, severity, pseudocholinesterase levels, and duration of ventilatory support are all factors to consider.This study emphasises the importance of prompt diagnosis and the initiation of early and effective treatment, which may result in fewer complications and lower mortality rates