Abstract
The objective of this paper was to observe the effects of Solanum lyratum Thunb extract on tumour inhibition, immune function and survival time of tumour-bearing mice. Lung carcinoma-bearing mouse model was established, the tumour-bearing mice were divided into model group, CTX group, Solanum lyratum Thunb extract high-dose group and low-dose group. By the examination of tumour inhibition rate of Solanum lyratum Thunb extract in Lewis lung carcinoma-bearing mice and determination of the number of NK cells and T cell subsets, the survival rate of tumour-bearing mice was observed. Solanum lyratum Thunb extract had some anti-tumour effect in Lewis tumour-bearing mice. The tumour inhibition rate of high-dose group reached 46.28%, and the tumour inhibition rate of low-dose group was 31.42%. Solanum lyratum Thunb extract can improve the NK cell activity of Lewis tumour-bearing mice, increase the number of CD4 cells in the tumour-bearing mice, and significantly increase the survival rate of tumour-bearing mice. The study concluded that Solanum lyratum Thunb extract has some anti-tumour effect and can improve immune function and survival rate of tumour-bearing mice.
Highlights
Solanum lyratum Thunb is the dried whole plant of Solanum lyratum Thunb in the genus Solanum of the family Solanaceae (Ming, 1985), which is mainly grown in places such as Anhui, Zhejiang and Jiangsu, on the roadsides and in the mountains and bushes
Studies have shown that Solanum lyratum Thunb has inhibitory effects on mouse sarcoma S180, uterine cervix carcinoma 14 and Ehrlich ascites carcinoma cells (Zhang, 2000), as well as anti-allergic effect
Tumour weights of tumour-bearing mice in CTX group and Solanum lyratum Thunb aqueous extract high- and low-dose groups were significantly reduced
Summary
Solanum lyratum Thunb is the dried whole plant of Solanum lyratum Thunb in the genus Solanum of the family Solanaceae (Ming, 1985), which is mainly grown in places such as Anhui, Zhejiang and Jiangsu, on the roadsides and in the mountains and bushes. Sun et al.’s (2003) experimental study showed that Solanum lyratum Thunb has a relatively strong antibacterial effect on a variety of bacteria such as streptococci and staphylococci; anti-inflammatory effect; hepatoprotective effect (Sun et al, 2003; Lu et al, 2003) and immune enhancing function (Kang et al, 1998; Sang et al, 1998). It was commonly used in combination with other drugs for the treatment of various cancers such as lung cancer, stomach cancer, pancreatic cancer and liver cancer (Wu et al, 2004; Yin et al, 2005)
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