Abstract
A study on the influence of the dissolution test factors on in vitro release of ibuprofen from sustained release tablets
Highlights
Release rate of APIs from solid pharmaceutical dosage forms and absorption rate is determined by dissolution so in vitro release plays an important role in predicting biopharmaceutical profile of a drug [1].According to the Biopharmaceutical Classification System (BCS), ibuprofen is included in class II
In vitro release of ibuprofen from sustained release matrix tablets depends on dissolution media pH and release rate depends on judicious choice of dissolution test factors to made precise in vitro/in vivo correlations
Hydrodynamic forces are much powerful in case of rotative paddle apparatus in comparison with rotative basket apparatus and in vitro release is more rapid
Summary
Release rate of APIs from solid pharmaceutical dosage forms and absorption rate is determined by dissolution so in vitro release plays an important role in predicting biopharmaceutical profile of a drug [1]. According to the Biopharmaceutical Classification System (BCS), ibuprofen is included in class II (due to its high permeability and low solubility). Bioavailability of pharmaceutical dosage forms containing APIs included in BCS II is limited by dissolution rate [2]. Modified-release dosage forms are used in therapy for more than 50 years and are an important field for pharmaceutical companies (R&D). An ideal MR dosage form can improve therapy and can offer the patient the following benefits: reduced administration frequency, adequate plasmatic concentrations, enhanced bioavailability and compliance [3]. Formulation of ibuprofen and the strategies applied to modulate its delivery, to acquire specific therapeutic
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