Abstract
The blood samples of 102 type 1 diabetic children aged under 15 years and 127 normal children were collected and their genomic DNAs were extracted.The single nucleotide polymorphisms rs1990760 and rs35744605 of interferon induced with helicase C domain 1(IFIH1)gene were detected. The results showed that the allele of IFIH1 rs35744605 in diabetes group and control group was the wild type G allele. The frequency of IFIH1 rs1990760 A allele in diabetes group was higher than that in control group(22.1% vs 13.0%, P=0.015), suggesting that IFIH1 rs1990760 A allele is associated with type 1 diabetes in Tianjin area. (Chin J Endocrinol Metab, 2018, 34: 50-52) Key words: Children, type 1 diabetes mellitus; IFIH1 gene; Polymorphism, gene
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