A Study on the Evaluation of Serum Uric Acid in Patients with Essential Hypertension

Abstract

ABSTRACT Background: Hyperuricemia can lead to nephrolithiasis and gout. It is an essential indicator of diseases like metabolic syndrome, cardiovascular disease, diabetes mellitus, and chronic renal disease. It indicates that hyperuricemia is associated with the risk of cardiorenal disease and new-onset hypertension. In older hypertensive patients, hyperuricemia is an essential indicator of cardiovascular risk for the development of hypertension. Methodology: A facility-based case-control study to identify the relationship between serum uric acid levels and hypertension, the relation between severity and duration of hypertension and the serum uric acid levels, and the relation between duration of hypertension and serum uric acid levels at tertiary care hospital. Sample size: 400; 200 cases and 200 controls. Adult male and female patients >18 years of age diagnosed as hypertensive according to JNC VII classification for hypertension were included. Patients with comorbidities are excluded. The method of uric acid estimation was done by the VITROS URIC Slide method. Results: The mean total cholesterol of cases was 159.18 ± 20.16, and controls were 125.21 ± 21.12. The mean high density lipoproteins (HDL) among cases was 36.33 ± 5.08, and controls were 45.64 ± 5.90. The mean low density lipoproteins (LDL) among cases was 124.99 ± 20.03, and controls were 104.48 ± 12.48. The mean triglycerides among cases was 172.58 ± 31.40, and controls were 131.21 ± 21.50. The mean serum uric acid level among males in the cases group was 6.1 ± 1.79, and among males in the control group, it was 5.2 ± 1.3. The mean serum uric acid level among females in the case group was 6.2 ± 1.92, and among the control group, it was 5.3 ± 1.1. The unpaired t-test was used and was statistically significant with a P value < 0.0001 among the above parameters. Conclusion: The study had a direct relationship between hyperuricemia and hypertension. Also, there is a positive correlation between the severity of hypertension and serum uric acid levels and higher hypertension of longer duration when compared to lesser duration.