A Study on The Effects of Two Doses of Testosterone on Some Biochemical Parameters in Male Rabbits

Abstract

The purpose of this paper was to investigate the effects of two doses of testosterone (T) on some biochemical parameters in male rabbits. Rabbits (15) were weighed and divided randomly into 3 groups (5 rabbits in each group): 1- control group (received 100 µl sesame oil), 2- low dose group (received 6 mg testosterone/kg b. w.), 3- high dose group (received 12 mg testosterone/ kg b. w.). The rabbits were injected with testosterone intramuscularly using 1 ml syringe once a week for 6 weeks. After the end of the 6 weeks period, the rabbits were weighed, slaughtered and blood samples were taken from the 3 groups for biochemical analysis. Both doses of T caused reduction in the concentration of glucose in the sera of the treated rabbits. However, only the high dose had a statistically significant effect when compared with the control. The hormone caused an increase in the concentration of serum total protein and cholesterol but had no significant effect on the concentration of serum albumin. The concentration of total cholesterol was found to decrease in a dose dependent manner. Even though the hormone caused a reduction in the concentrations of glucose and cholesterol which could be significant for those who are suffering from diabetes and hypercholesteremia, damage to the liver could not be excluded