Abstract
The right atrial tissues obtained at the time of coronary bypass surgery were studied for release of prostacyclin and thromboxane. Human, right atrial tissues are capable of producing thromboxane A2 (TXA2) in addition to prostacyclin. Indomethacin and Aspirin by inhibiting generation of cyclic endoperoxides inhibited synthesis of both prostacyclin and TXA2 In contrast a thromboxane synthethase inhibitor U63557A selectively inhibited TXA2 without significant effects on prostacyclin synthesis. The study points to the superiority of thromboxane synthetase inhibitor U63557A over Aspirin or Indomethacin and represents an important approach to platelet inhibition by selectively inhibiting thromboxane synthesis without affecting the synthesis of prostacycline.
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