Abstract
Objective: To explore the effects of anxiety and depression on the self-management ability and endogenous creatinine clearance rate of renal transplant patients.Method: Eighty-eight renal transplant recipients who were followed up in the outpatient clinic of the Affiliated Hospital of Zunyi Medical University were selected using convenient sampling. The self-made general data sheet, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and Self-Management Scale for Kidney Transplant Recipients were used. Correlation analysis was used to find factors related to endogenous creatinine clearance, while multiple linear regression was used to identify factors influencing endogenous creatinine clearance. Patients with or without anxiety and depression were divided into groups, and the indexes of the groups were compared using the independent samples t test, rank-sum test, or chi-squared test.Results: Anxiety was present in 12.5% of patients, depression in 25%, and a moderate level of self-management in 34.1%. Only 9.1% of renal transplant recipients had endogenous creatinine clearance within the normal range, and 34.1% had a body mass index not in the normal range (25% were overweight, and 9.1% were underweight). The endogenous creatinine clearance rate was negatively correlated with age and degree of depression, and positively correlated with body mass index, treatment management score, and psychosocial management score. The main influencing factors of endogenous creatinine clearance rate were age, sex, depression, body mass index, and treatment management score. The endogenous creatinine clearance rate and psychosocial management ability were significantly higher in patients without anxiety and depression than in patients with anxiety and depression (all P < 0.05).Conclusions: Anxiety and depression showed significant negative effects on the psychosocial self-management ability and endogenous creatinine clearance rate of renal transplant recipients and thus should be given more attention.
Highlights
Renal transplantation is currently recognized by the international medical community as the best treatment for patients with end-stage renal disease that can significantly improve survival and quality of life [1, 2]
Using the independent samples t-test, we found that the age and body mass index of patients with anxiety and depression were higher than those without anxiety and depression; the difference was not statistically significant (P > 0.05)
When the rank-sum test was used to compare the groups, the results showed that the scores for diet management, treatment management, physical activity management, and psychosocial management and the total score of self-management scale in the anxiety and depression groups were lower than those in the nonanxiety and depression groups
Summary
Renal transplantation is currently recognized by the international medical community as the best treatment for patients with end-stage renal disease that can significantly improve survival and quality of life [1, 2]. While patients benefit from the procedure, they face many challenges, such as the need to make immunosuppressants for a long time and undergo regular monitoring, occurrence of rejection reactions, and risk of infection after transplantation [3]. They experience higher incidences of diabetes, tumor, and other comorbidities [4, 5]. Endogenous creatinine clearance is a crucial index to assess the damage of glomerular filtration function and evaluate renal function At present, it has replaced the glomerular filtration rate as the standard for staging chronic renal insufficiency in clinical practice
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