A study on the Clinical profile of fever with thrombocytopenia

Abstract

Common manifestations during monsoon conditions in tropical regions are specified with fever and thrombocytopenia. With this, viral disease like dengue, chikungunya, malaria is more common. Hence it is important to evaluate and diagnose the manifestation thereby bringing in early treatment and reduced mortality. The present study was designed to evaluate the clinical profile of patients with fever and thrombocytopenia and its clinical outcome. Prospective non-interventional observational study was conducted in a tertiary care hospital with 160 patients by random sampling. Patients with fever were involved for the study, their clinical data (symptoms during presentation, signs of fever), laboratory examinations for platelet count, total leukocyte count, and liver function tests were performed. Follow-up was maintained until patients were discharged or with record of mortality. Data was analysed using Chi-square test and Cramer’s V test. Out of total 160 patients, majority were male with gender ratio of 7:3 (male:female0 and mean age was 32.53±15.23 years. Majority of patients depicted that the total platelet count was in the range of 40001-60000/ccum and was significantly dependent on etiology (P=0.03198). Similarly, total leukocyte count was also significantly dependent on etiology (P=0.0004998). Fever and thrombocytopenia are the early manifestations of the major viral diseases. Hence it is important to systemically study the clinical and laboratory data to determine its etiology and early diagnosis for treatment.