Abstract
The coronary inflow was measured with the cannulation method and the blood pressure was recorded by means of an Hg-manometer in anesthetized dogs placed on artificial respiration. The effects of the intracoronary and intravenous injections of veratrum alkaloids, nucleic acid derivatives, cardiac glycosides, autonomic drugs, histamine, posterior pituitary extract, inorganic salts, and metabolic inhibitors on the coronary blood flow, the heart rate, the blood pressure and the cardiac movment were observed in intact and vagosympathectomized dogs, and in dogs pretreated with autonomic blocking agents, as well as in the heart-lung preparation. From these results, the relation of the cardiac reflex eliciting action of drugs to the chemical structures, the cardiac actions, the effects on the coronary vessel, and the cardiac metabolism were discussed.
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