A study on the antioxidant defense system of psoriasis patients in the ethnic population of Kashmir-India

Abstract

The study was designed to evaluate the role of antioxidant defense system in the etiology of psoriasis, a chronic skin disorder of complex etiology and pathology. Hospital-based case–control study was carried out in major referral hospital in Kashmir, North India. Cases (N = 40) were composed of patients with psoriasis vulgaris, and controls (N = 20) were healthy volunteers. Study included estimation in plasma of both patients and controls of glutathione (GSH) levels, superoxide dismutase (SOD) activity, and total antioxidant potential (AOP) as indices of antioxidant defense system and malondialdehyde (MDA) as a measure of lipid peroxidation (LP), an indicator of oxidative stress. The GSH levels, SOD activity, AOP, and malondialdehyde levels in plasma of psoriasis patients were 2.58 ± 0.22 μM/l, 5.24 ± 0.69 U/ml, 0.020 ± .011 nmol−1/ml h, and 0.88 ± 0.20 nmol/ml and were 4.76 ± 0.52 μM/l, 4.14 ± 0.56U/ml, 0.042 ± 0.018 nmol−1/ml h, and 0.53 ± 0.16 nmol/ml in healthy voluntary controls, respectively. A significant decrease in GSH levels (p < 0.005) and AOP (p < 0.005) and significant increase in SOD activity (p < 0.01) MDA levels (p < 0.005) as an indicator of LP was observed.