Abstract
Paralysis in man and the domestic fowl caused by “T o CP” (tri-cresyl phosphate, tri-tolyl phosphate or TTP) is reviewed, and the search for a non-toxic plasticizer derived either from TTP or tri-xylenyl phosphate (tri-dimethylphenyl phosphate or TXP) is described. It had been previously shown that the ortho -tolyl esters are toxic but we found that their removal does not make the mixture non-toxic. The meta - and para -tolyl esters were known to be free from toxic effects and the 2: 4 and 2: 5 dimethylphenyl esters were equally shown to be non-toxic except in massive doses. We confirmed that the tri- ortho -ethylphenyl ester was non-toxic, but found the mono- and di- ortho -ethylphenyl phosphates to be highly toxic. We showed that TTP made from phenols with all the ortho -cresol and ortho -ethylphenol removed is non-toxic. With TXP, however, elimination of all ortho -cresol and ortho -ethylphenol from the raw materials does not result in a non-toxic plasticizer. Tri- ortho - n -propylphenyl phosphate was shown to non-toxic but esters containing one or two ortho -propylphenyl groups are toxic. The toxicity of the ortho -tolyl, ortho -ethylphenyl and ortho -propylphenyl groups is much reduced in the presence of the 3: 5-dimethylphenyl group. This influence is greatest in mono- ortho -propylphenyl-di-3: 5-dimethylphenyl phosphate which is non-toxic in five consecutive daily doses of 500 mg./kg. body weight. The removal of all ortho -cresol, ortho -ethylphenol and ortho -propylphenol from the raw material results in a non-toxic product which we termed non-toxic plasticizer “NTP”. This has been fed in various doses to a variety of mammals and a large number of chickens in short term tests without toxic effects. Our experiments showed that tri- meta -ethylphenyl phosphate is non-toxic but tri- para -ethylphenyl phosphate is highly toxic. The mixture from which NTP is made contains 10% of para -ethylphenol. Based on chemical statistics the tri- para -ethylphenyl ester can be present only in minute quantities, and we have shown that esters containing one or two para -ethylphenyl groups are non-toxic. An ester with a methyl group in the ortho , and an ethyl group in the para position in the same benzene nucleus (tri-2-methyl-4-ethylphenyl phosphate) we showed, surprisingly, to be non-toxic.
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