A study on serum cholinesterase level in deaths due to organophosphorus compounds poisoning

Abstract

Organophosphorus compounds are widely used in agriculture and horticulture. Poisoning by these organo phosphorus compounds are accidental exposure or with suicidal intention. Self consumption of organophosphorus compounds is a common worldwide health problem..These compounds are absorbed through skin, conjunctiva, lungs, and gastro intestinal tract. Immediately after absorption these compounds inhibit the enzyme acetyl cholinesterase leading to accumulation of acetylcholine producing morbidity and mortality. Pralidoxime and atropine are the drugs of choice in the treatment of OP poisoning. The aim of the study is to estimate the serum cholinesterase levels in deaths due to OP poisoning. 1.1 Method of study: Prospective study. 36 subjects who died from OP poisoning, in the Rajiv Gandhi government general hospital, subjected for autopsy, to the Institute of Forensic Medicine, Madras Medical College, were selected. 28 were males and 8were females. Serum cholinesterase level was done at the Institute of Biochemistry, Madras medical college, Chennai. The mean serum cholinesterase level was 1675+/-1228U/L.(Normal range . 6971-11900U/L). 3 Though there are various comorbid conditions that predict the morbidity and mortality in organophosphorus poisoning , the serum cholinesterase estimation is of diagnostic value in Forensic Practice.