A STUDY ON PROGNOSTIC VALUE OF SERUM LACTATE DEHYDROGENASE AND CREATINE PHOSPHOKINASE LEVELS IN DENGUE FEVER

Abstract

Worldwide about 100 million people are affected with dengue fever every year. Dengue is the most widely distributed mosquito-borne viral infection of humans1. In categorization of South East Asian countries for dengue fever, India is considered under Category-A where it is a major public health problem with hyperendemicity of all 4 serotypes in urban areas and spreading to rural areas2. India being a developing country there is a need for better utilization of resources to predict the severity of disease. Assessment of severity is essential for further management of the disease.In this study, we looked at the prognostic value of lactate dehydrogenase(LDH) and creatine phosphokinase(CPK). To study the predictive value of LDH and CPK in dengue feve AIM: Methods and r according to severity. materials: 85 patients of different severities of Dengue fever admitted to NRIGH are taken into a cross sectional prospective study and assessed. Dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are the different stages of severity taken into account. Statistical analysis: Statistical data analysis included mean, standard deviation, median, percentage and its level of signicance. Results of laboratory parameters (continuous measurements) are displayed as mean ± standard deviation, median and range. Frequency (Categorical) measurements are presented as numbers and percentage. Paired t-test, Mann Whitney U test and Fischer's Exact Test are applied as necessary. Results: Among 85 patients with dengue fever, 78 were having DF, 6 had DHF and 1 had DSS. The mean age of the patients included in the study was 38.7 years with standard deviation of 15.6. Maximum number of individuals was within the age group of 20 – 39 years. The eldest in the study was 73 years. This study showed no statistically signicant correlation between CPK levels and severity of dengue fever. Conclusion: Studies done at different parts of the world showed signicant correlation between serum LDH and CPK levels. This study didn't nd signicant correlation between serum LDH levels, serum CPK levels with severity of dengue fever but signicant variation was noted in CPK and LDH levels among dengue subtypes. Probably lack of equal proportional cases from different subtypes we couldn't nd correlation. Study with larger sample size and proportional cases in different subtypes might be required to test the correlation.