A Study on Phytochemical Profiling, Antibacterial and Anticancer Activity of Cordia obliqua Willd Methanolic Fruit Peel Extract

Abstract

The purpose of this work is to highlight some of the biological activities of Cordia obliqua Wild fruit peel methanolic extract. The phytochemical screening of C. obliqua extracts (Chloroform, Methanol and Hexane) was performed; among the three extracts, only methanolic exhibited greater activity. Methanolic fruit peel extracts revealed that the presence of phenol, flavonoids, alkaloids, Saponins and Glycosides. DPPH Assay demonstrated that C. obliqua has the highest scavenging activity in methanolic fruit peel extract. The results of antibacterial activity of the tested methanolic fruit peel extract against four pathogenic bacterial strains such as Salmonella sp. (4.0±0.141), Escherichia coli (5.4±0.223), Bacillus cereus (7.1±0.302) and Staphylococcus aureus (6.1±0.26).Anticancer activity of C. obliqua methanolic fruit peel extract was carried out MDA-MB-231 cell line. At the end of 48 hrs of IC50 of 269.03μg/ml, 50% cell viability was observed by following MTT Assay. According to the findings of this study, the active compound found in the C. obliqua methanolicfruit peel extract could be a potent source of natural antioxidants, which are important as a therapeutic agent in preventing or slowing the progression of ageing, age-related oxidative stress, and related degenerative diseases. More research is needed to properly characterize the key ingredients responsible for antioxidant and anticancer action. Keywords: Cordia oblique, Antibacterial activity, Antioxidant and Anticancer