Abstract
Abstract On the basis of staining, cultural properties, and in vitro sensitivity reactions to certain antimicrobial agents the scotochromogens are unlike the common saprophytic mycobacteria and tubercle bacilli. They form a group distinct from these. Their bacteriologic characteristics are more like those of photochromogens. A notable difference is that photochromogens need light for synthesis of pigment. Resistance to acid-alcohol decolorization, tolerance to p -aminosalicylate and less so to streptomycin, ability to grow on suboptimal media and at room temperatures, and the capacity to form pigment independent of light are useful criteria for identification of scotochromogens. A chronic suppurative inflammatory response was produced in guinea pigs. The histologic picture is not typical of tuberculosis although epithelioid tubercles and/or atypical multinucleated giant cells were present in a number of infected animals occurring particularly in the liver.
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