Abstract
Introduction: Retinopathy of prematurity (ROP) chiefly affects preterm infants. With the increased survival of extremely preterm infants, the number of infants with severe ROP has also increased. Objective: To assess the incidence, associated factors and outcome of ROP in neonates born at less than 34 weeks of gestation and/or less than 1.5 kg birth weight in Sri Jayawardenepura General Hospital Method: A prospective, descriptive, observational study was conducted in neonates born from 01/01/2014 to 31/12/2014, who were less than 34 weeks of gestation and/or less than 1.5 kg birth weight. Data was collected from patient records. Incidence estimates were given using descriptive statistics. For bivariate analysis (where associated factors were considered), the Chi Square test was applied to assess significant associations. The level of significance was 0.05. Results: Of 126 neonates, 113 were included in study as 11 met exclusion criteria and 2 dropped out during follow up. Twenty eight (24.8%) neonates had ROP of whom 12 (42.9%) needed treatment. Study revealed that, earlier the gestation and lower the birth weight, ROP was more commonly observed. Patent ductus arteriosus (PDA) (p=0.006), sepsis (p=0.024), invasive ventilation for 7 or more days (p=0.0001) and supplementary oxygen for more than 7 days (p=0.0001) were significantly associated with development of ROP. Conclusions: Incidence of ROP at Sri Jayawardenapura General Hospital in 2014 was 248/1000 live births of neonates less than 34 weeks gestation and/or birth weight less than 1.5 kg. PDA, sepsis, invasive ventilation for more than 7 days and oxygen supplementation for more than 7 days were significantly associated with occurrence of ROP. Sri Lanka Journal of Child Health , 2017; 46 (4): 322-325
Highlights
Retinopathy of prematurity (ROP) affects preterm infants
Patent ductus arteriosus (PDA) (p=0.006), sepsis (p=0.024), invasive ventilation for 7 or more days (p=0.0001) and supplementary oxygen for more than 7 days (p=0.0001) were significantly associated with development of ROP. 1Senior Registrar in Neonatology, Castle Street Hospital for Women, Sri Lanka, 2Medical Officer, Sri Jayawardenepura General Hospital, Sri Lanka, 3Consultant Neonatologist, Sri Jayawardenepura General Hospital, Sri Lanka *Correspondence: ikaliyanage@gmail.com (Received on 03 February 2017: Accepted after revision on 17 March 2017) The authors declare that there are no conflicts of interest Personal funding was used for the project
PDA, sepsis, invasive ventilation for more than 7 days and oxygen supplementation for more than 7 days were significantly associated with occurrence of ROP
Summary
Retinopathy of prematurity (ROP) affects preterm infants. With the increased survival of extremely preterm infants, the number of infants with severe ROP has increased. Retinopathy of prematurity (ROP) affects preterm infants[1]. With the increased survival of extremely preterm infants, the number of infants with severe ROP has increased[2,3]. The international classification of ROP (ICROP) was first published in 1984 and later expanded in 1987. Further aspects of ICROP were revised and published in 2005. Stage I is characterized by a line of demarcation. The line of demarcation separates the vascularized portion of the retina from the anteriorly positioned avascular retina
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