Abstract
Metabolic Impact of Nigella sativa extracts on Experimental Menopause Induced RatsSaadat Parhizkar, Latiffah A. Latiff, Sabariah A. Rahman, Parichehr Hanachi, Mohammad Aziz Dollah
Highlights
Renal transplantation is the surgical placement and vascular integration of a human kidney from a living or cadaveric donor into a patient who has end stage renal disease (ESRD)
Dyslipidemia is associated with higher incidence of graft loss and renal transplant recipients should be effectively managed with dose intense statin therapy or other safer immunosuppressants
The study has analyzed the differential effects of immunosuppressants on serum lipids and Total Cholesterol, LDL-C, HDL, VLDL and Triglycerides and has determined immunosuppressants as a significant predictor of developing dyslipidemia in renal transplant recipients
Summary
Renal transplantation is the surgical placement and vascular integration of a human kidney from a living or cadaveric donor into a patient who has end stage renal disease (ESRD). It is the only treatment modality that restores reasonable renal function in ESRD patients (Wallace, 1998). Renal function is restored to some extent, renal transplantation possesses various short term and chronic complications, the most important being cardiovascular and post-transplant metabolic syndrome (PTMS) (Stephanie et al, 2009; Oruc et al, 2013). Cardiovascular complications remain the major cause of morbidity and mortality in renal transplant recipients (Kasiske et al, 1996). These long term complications are not direct effects of grafting but are caused due to the dose intense immunesuppressant and long term steroid therapy. The US National cholesterol education program – Adult treatment panel III defines metabolic syndrome as the presence
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