Abstract
Coumarin compounds are δ-lactones where α-pyrone ring is fused with benzene ring. Coumarins are widely distributed in the plant kingdom as well as they are very important in synthetic organic chemistry. Coumarins have great interest because of their abundance in nature and diverse pharmacological activities including antibacterial, antiviral, antipyretic, and anticoagulant, antioxidant, anti-inflammatory and anticancer. This study focused on synthesizing different simple Coumarins and studying their antioxidant activity. Four simple Coumarins (Coumarin (C1), 4-hydroxy coumarin (C2), 7-hydroxy coumarin (C3) and 7-hydoxy-4-methyl coumarin (C4)) were synthesized by using standard methods and were characterized by using UV, IR, 1H and 13C NMR spectra. Antioxidant activity of the simple Coumarins was studied by using standard FRAP assay and Hydrogen peroxide assay and expressed as FRAP value (mmol Fe2+/g) and IC50 value (mg/dm-3) respectively. Ascorbic acid was used as standard. All synthesized simple Coumarins showed both antioxidant activities. Hydroxyl Coumarins (C2, C3 and C4) showed higher activities in both cases than C1. Among the hydroxyl Coumarins C3 showed highest hydrogen peroxide scavenging activity and Ferric reducing capacity too. Antioxidant power of the tested simple Coumarins in decreasing order was C3, C2, C4 and C1 in both cases. But the hydrogen peroxide scavenging activity and Ferric reducing capacity of the all synthesized simple Coumarins were lower when compared to standard ascorbic acid.
Highlights
Coumarin compounds represent an important class of naturally occurring and synthetic heterocyclic compounds
Recent study shows the occurrence of coumarin derivative (Versicolone A) in insect – associated fungus, Aspergillus versicolor too [5].The Simple coumarins are the hydroxylated, alkoxylated and alkylated derivatives of the parent compound, Coumarin
Several researches have been carried out to study the antioxidant activity of various coumarins
Summary
Coumarin compounds represent an important class of naturally occurring and synthetic heterocyclic compounds They have α-benzopyrone framework where, a benzene ring is fused with α-pyrone ring (Figure 1). In addition Coumarins have been studied to use as diagnostic agent, supramolecular medicinal drugs, pathologic probes and biological stains to monitor enzyme activity as well as pharmacokinetic properties in cells [3]. The high oxidative stress formed by the ROS causes deleterious effects to the human body. Several researches have been carried out to study the antioxidant activity of various coumarins. Hydroxyl radical attacks the molecules on its path in human body and oxidize it into unstable radical It propagates a chain reaction and giving well significant contribution to the harmful effects of high oxidative stress. Cooled product was collected and recrystallized from aqueous methanol [19]
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