Abstract
Female lives longer than male and incidence of cardiovascular disease is lower in young female. However the role of oxidative stress has been repeatedly described in various diseases but rarely healthy people. The objective of the study was to observe the gender related differences in oxidative stress status and to show significance in alteration. This cross sectional and comparative study was carried out in the Department of Physiology, Rajshahi Medical College during the period from January 2013 to June 2014. Total 45 healthy adult subjects (25 males and 20 females) were enrolled in the study. Systematic sampling technique was used to select each study subject from students, doctors and staffs of Rajshahi Medical College. Malondialdehyde (MDA), a lipid peroxide and alpha-tocopherol, an antioxidant in plasma was measured. MDA:alpha-tocopherol ratio was used as a reliable marker of oxidative stress status. The mean plasma alpha-tocopherol concentration was significantly higher (p < 0.05) and plasma MDA: alpha-tocopherol ratio was significantly lower (p < 0.05) in female group than male group. The mean plasma alpha-tocopherol concentration was significantly higher (p < 0.05) in female group aged 18-21 years than the corresponding male group. From the results of this study, it can be concluded that oxidative stress is less in female than in male indicating presence of potent compensatory response against oxidative stress in female which may be attributed to influence of female sex hormones.
 Mediscope Vol. 6, No. 1: Jan 2019, Page 13-18
Highlights
Oxidative stress results from the imbalance between oxidative and anti-oxidative mechanisms with increased levels of pro-oxidants and depletion of anti-oxidants leading to tissue damage
We found that the plasma MDA levels were non-significantly higher but plasma alpha-tocopherol levels were significantly higher in females than males
In this study, we found that oxidative stress was less in female than male due to presence of potent compensatory response against oxidative stress
Summary
Oxidative stress results from the imbalance between oxidative and anti-oxidative mechanisms with increased levels of pro-oxidants and depletion of anti-oxidants leading to tissue damage. The human body generally has anti-oxidant system, which plays an important role in the suppression of ROS over production and protects cells from oxidative stress. 2. MOI Ali, MBBS, MPhil, Associate Professor of Physiology, Rajshahi Medical College, Rajshahi 3. SA Latif, MBBS, MPhil, Professor of Physiology and Member of Bangladesh Public Service Commission whereby polyunsaturated fatty acids in cell membranes undergo degradation to form lipid hydro-peroxides. These latter compounds decompose to form a wide variety of products including Malondialdehyde (MDA).[2] MDA is a three carbon, low molecular weight aldehyde that can be produced from free radical attack on polyunsaturated fatty acids of biological membranes. The determination of MDA is used for monitoring lipid peroxidation in biological samples.[1]
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