A STUDY ON DRUG RESISTANCE IN VARIOUS INFECTIOUS DISEASES

Abstract

Comparative investigations were performed on 200 cases of various infectious diseases, recently treated, for resistances of different pathogenic bacteria to 7 drugs : Sulfathiazole (St), Penicillin (PC), Dehydrostreptomycin (SM), Chloramphenicol (CM), Tetracycline (TC), Erythromycin (EM), Leucomycin (LM).As a whole, St resistance with 85% and PC resistance with 74% ranked highest, TC, EM and LM resistance ranging 4050%, were intermediate, and SM and CM resistance with about 30% were the lowest. This tendency was more or less observed in all diseases and for all bacteria.As for difference between in-and out-patients, resistances of the former were higher than those of the latter to all the drugs by about 10-15%.This tendency was recognized in each disease.St, PC and EM resistance in diseases of digestive system ranged 90-100%, which were higher than in any other disease. As contrast, SM and CM resistance in oto-rhino-laryngological diseases were lowest with 0-3%. Relatively high St and PC resistance were found for Shigella dysenteriae, Escherichia coli and Pseudomonas aeruginosa, and relatively low SM and CM resistance for Gram-negative bacilli, Staphylococci and Diplococcus pneumoniae.Multiresistance to 4 drugs (St. PC, SM and CM) with sensitivity of 8% was extremely infrequent, but those to 3 and 4 drugs with resistance of 36% were remarkably frequent.These results were compared with reports by various other workers. and it was pointed out necessary to establish accordingly adequate therapies and counter-plans from view point of public health.