Abstract
Objective: The objective of the study was to study the pattern of various types of cutaneous adverse drug reactions (CADRs) and its relation to therapeutic agents.
 Methods: A retrospective study was carried out in the Department of Pharmacology, Meenakshi Medical College Hospital and Research Institute. Pharmacovigilance reports collected from 2017 to 2019 which were probable and certain by the WHO causality assessment were included in the study. Descriptive statistics were used. Values were expressed in numbers and percentage.
 Results: Adverse drug reactions (ADRs) of 40 patients were selected based on the inclusion criteria, of which 22 were female (55%) and 18 males (45%). Patients aged <50 years had more incidence (77.5%) of ADRs. Cutaneous manifestations contributed to major ADRs (67.5%). CADRs were more common with antibiotics (55.5%) followed by nonsteroidal anti-inflammatory drugs (14.6%).
 Conclusion: The most common therapeutic agent of CADRs were antibiotics (fluoroquinolones and cephalosporins) and the frequent cutaneous manifestation was urticaria.
Highlights
Pharmacotherapy is aimed at relieving the sufferings, but sometimes they themselves can cause adverse drug reactions (ADRs)
Studies have found the incidence of Cutaneous ADRs (CADRs) in developed countries as 1–3%, while in developing countries, it is higher between 2% and 5% [2,3,4]
The most common causative drugs causing these ADRs were antimicrobials followed by nonsteroidal anti-inflammatory drugs (NSAIDs)
Summary
Pharmacotherapy is aimed at relieving the sufferings, but sometimes they themselves can cause adverse drug reactions (ADRs). ADRs are noxious, unintended reactions occurring at normal doses. They are the important cause of increased health expenditure, morbidity, hospitalization, and even death [1]. Cutaneous ADRs (CADRs) are among the most frequent ADRs. Studies have found the incidence of CADRs in developed countries as 1–3%, while in developing countries, it is higher between 2% and 5% [2,3,4]. Active search is essential in identification of these CADRs, as both the patients and health-care professionals may tend to downplay the causal association between drug use and subsequent cutaneous manifestation. The purpose of this study was to assess the incidence and the pattern of CADRs and its causal association with drugs
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