Abstract
Background: Perinatal asphyxia is one of the major causes of neonatal morbidity & mortality. Asphyxia can damage almost every organ of neonate. Our purpose was to determine the correlation of cord blood pH with birth asphyxia & early neonatal outcome. Subjects and Methods: A prospective study was conducted over a period of one year at STH Haldwani. We enrolled 108 term neonates with signs of fetal distress, thick MSL, non-reassuring NST & there were subjected for estimation of umbilical cord blood pH, APGAR score, outcome looked were resuscitation needed, NICU admission, delay in feed & encephalopathy (sarnat & sarnat stage). Results: In our study, cord blood pH had significant correlation with perinatal asphyxia(R=-0.926). Area under ROC curved showed that mean pH <7.1 (ROC=0.998) is very significant in predicting the adverse outcome. Conclusion: Cord blood pH is very sensitive and specific & has good correlation in predicting the birth asphyxia & adverse neonatal outcome. Measurement of cord blood pH is recommended in all the neonates with signs of fetal distress.
Highlights
Perinatal asphyxia is a most common preventable cause of neurological injury in new borns & a leading factor which significantly increases the neonatal morbidity and mortality
A precise definition of birth asphyxia is given by the American College of Obstetrician and gynaecologists (ACOG), American Academy of Paediatrics (AAP) includes existence of 3 factors: Metabolic or mixed academia which is determined by umbilical cord arterial blood samples; APGAR score of
It is necessary to identify the babies, who will be at high risk for intrapartum hypoxia & poor neonatal outcome, early death as a complication of asphyxia
Summary
Perinatal asphyxia is a most common preventable cause of neurological injury in new borns & a leading factor which significantly increases the neonatal morbidity and mortality. It is characterized by an impairment of exchange of the respiratory gases (oxygen and carbon dioxide) resulting in hypoxemia and hypercapnia, accompanied by metabolic acidosis. A precise definition of birth asphyxia is given by the American College of Obstetrician and gynaecologists (ACOG), American Academy of Paediatrics (AAP) includes existence of 3 factors: Metabolic or mixed academia (pH
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