A Study on Correlation of Serum Sodium with the Complications of Chronic Liver Disease

Abstract

Introduction: Cirrhosis is mostly initiated by alcoholism and hepatitis C, however certainly has many other possible reasons, such as Wilson's disease, hemochromatosis, autoimmune hepatitis, and non-alcoholic fatty disease. Hyponatremia occurs when serum sodium concentration in the blood is less than 135mmol/L, with severe hyponatremia being below 120 mmol/L. In the current study, lower serum sodium levels were associated with improved complications of decompensated chronic liver and mortality leading to the integration of sodium. Aim of the Study: The study aimed to investigate the correlation of serum sodium with the complications of chronic liver disease. Methods: A Prospective cross-sectional study was carried out Department of Gastroenterology and Hepatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shabagh, Dhaka, from March 2014 to February 2015. A total of 100 patients (N=100) for one year were enrolled in this study following the inclusive criteria. Data were collected using the predesigned semi- structured questionnaire. Verbal consent was taken before recruiting the study population. Completed data forms were reviewed, edited, and processed for computer data entry. Result: Among hundred patients (N=100) with decompensated chronic liver disease observe the impact of hyponatremia with the severity of complications. Of them, it was observed that more than one-third of the patients (37,37.0%) belonged to age 31-40 years. The mean age was found 42.2±SD years. It was observed that almost two-thirds of the patients (63,63.0%) were male and thirty-seven (37,37.0%) patients were female. Among the study population, the majority of the patients (90,90.0%) belonged to serum sodium ≤135 mmol/l (Hyponatremia). The mean serum sodium was found 124.7±SD mmol/l. The majority of patients (57,57.0%) had moderate ascites, nineteen patients (19,19.0%) had mild and about one-fourth of the patients (24,24.0%) had severe ascites. In his current analysis, ............