Abstract
A study on acute disseminated encephalomyelitis in children
Highlights
Acute disseminated encephalomyelitis (ADEM) is an acute demyelinating disorder of central nervous system characterized by scattered focal / multifocal inflammation of brain & spinal cord that usually follows an apparently benign infection in otherwise healthy children & young adults
It represents 30% of all childhood encephalitic illnesses [1]. It is considered as an autoimmune disorder that is triggered by environment stimulus in genetically susceptible individuals. It is usually presenting as a monophasic disorder associated with multifocal neurological symptoms & encephalopathy
Inclusion Criteria: Study group consisted of hospitalised children < 15 years of age admitted to the indoors of SCB MCH & SVPPGIP, Cuttack with the diagnosis of ADEM as per the defined criteria i.e.,1 Acute / sub-acute onset of polysymptomatic2 neurological presentation with prominence of cortical signs preferably with a preceding history of infectious illness or vaccination [1,2,3 4,5,6,7]. 2
Summary
Acute disseminated encephalomyelitis (ADEM) is an acute demyelinating disorder of central nervous system characterized by scattered focal / multifocal inflammation of brain & spinal cord that usually follows an apparently benign infection in otherwise healthy children & young adults. It represents 30% of all childhood encephalitic illnesses [1]. Because of significant advances in infectious disease control & extensive immunisation coverage, nonspecific upper respiratory illness are the most common triggering event in developing countries, but the exact aetiological agent
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