Abstract
Five novel 3-alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with phenylacetyl chloride and characterized by elemental analyses and IR, 1HNMR, 13C-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide, and the half-neutralization potential values and the corresponding pKa values were determined for all cases. In addition, these new compounds and five recently reported 3-alkyl-4-(pmethoxybenzoylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were screened for their antioxidant activities.
Highlights
Nowadays, antioxidants have become one of the major areas of scientific research
Antioxidants are extensively studied for their capacity to protect organisms and cells from damage that is induced by oxidative stress
Scientists in many different disciplines have become more interested in new compounds, either synthesized or obtained from natural sources, that could provide active components to prevent or reduce the impact of oxidative stress on cells [19]
Summary
Muzaffer Alkan 1, Haydar Yüksek 1,*, Fatih İslamoğlu 2, Şule Bahçeci 3, Mustafa Calapoğlu 1, Mahfuz Elmastaş 4, Hüseyin Akşit 4 and Mustafa Özdemir 5. Received: 28 May 2007; in revised form: 2 August 2007 / Accepted: 2 August 2007 / Published: 13 August 2007
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