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Abstract
In high-shear wet granulation, breakage and attrition play an important role but are the least understood among all rate processes. To understand these phenomena, experiments were performed in a breakage-only granulator using pre-made granules. Non-granulating wet sand was used as the shearing medium in the granulator. A size analysis of the granules was done before and after the experiment for each trial in order to get a rough estimate of the size range of the granules after the breakage experiment. The number of granules broken and the granules mass change (before and after the experiment) were recorded after each experiment, in order to measure the extent of granule breakage in a granulator. Experimental results showed that formulation properties and operating parameters significantly influence the breakage behaviour. Population balance simulations were performed for breakage-only granulation and the simulation results were found to be in reasonable agreement with the experimental results.
Published Version
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