Abstract
Aim: The aim of this studywas to measure the Vitamin-C levels in chronic kidney disease patients. Chronic renal failure is a clinical syndrome resulting in the progressive loss of renal function. The symptoms of chronic renal failure result not only from simple excretory failure but also from the onset of regulating failure, the kidney’s failure to regulate certain substances, such as sodium & water. According to National Kidney Foundation- Kidney Dialysis Outcomes Quality Initiative (NKF-KDOQI) guidelines CRF is classified into 5 stages. An increased oxidative stress and inflammation are both common features of end stage renal disease. Methods: Here, we determined the vitamin-C levels in patients with chronic kidney disease and the antioxidant status of vitamin-C in these patients. Results: The mean plasma Vitamin – C concentration has found to be decreased in CKD patients when compared with the controls. Conclusion: Vitamin C improves endothelial function in the resistance vasculature of patients with chronic renal failure, and this effect was abolished by an inhibitor of nitric oxide (NO) synthesis.There is insufficient evidence to recommend the use of vitamin C (ascorbate) in the management of patients with CKD.
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